Article

p75NTR modulation by LM11A-31 counteracts oxidative stress and cholesterol dysmetabolism in a rotenone-induced cell model of Parkinson’s disease

2024-12-25

Abstract excerpt

Neurotrophins play pivotal roles in the development and proper functioning of the nervous system. The effects of these growth factors are mediated through the binding of high-affinity receptors, known as Trks, as well as the low-affinity receptor p75NTR. The latter has the capacity to induce complex signal pathways, as it favors both pro-survival and pro-apoptotic cascades depending on the physiopathological condi...

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Literature Corpus work: 94b8cf50-ecdd-5d6e-bd46-20d550686436
DOI: 10.1101/2024.12.25.630306

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