Article

Vectofusin-1–based T-cell transduction approach compared with RetroNectin-based transduction for generating murine chimeric antigen receptor T-cells

2021-08-28

Abstract excerpt

Gene transfer into human and murine T-cells using viral-based approaches has several promising therapeutic applications including the production of chimeric antigen receptor T-cell (CAR-T) therapy. The generation of murine CAR-T is paramount to test and validate immunocompetent mouse models for CAR-T therapy. Several viral transduction enhancers already exist for gene therapy with few limitations. In this study, w...

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Literature Corpus work: 94a5abb3-d9f6-5db9-83fd-aa2ce86380e2
DOI: 10.1101/2021.08.28.458011

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