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Vectofusin-1 Promotes RD114-TR-Pseudotyped Lentiviral Vector Transduction of Human HSPCs and T Lymphocytes

8 Mar 2017

Abstract excerpt

Ex vivo transduction of human CD34 + hematopoietic stem/progenitor cells (hCD34 + HSPCs) and T lymphocytes is a key process that requires high efficiency and low toxicity to achieve effective clinical results. So far, several enhancers have been used to improve this process. Among them, Retronectin highly meliorates VSV-G and RD114-TR pseudotyped lentiviral vector delivery in hCD34 + HSPCs and T lymphocytes....

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PMID: 28480301
DOI: 10.1016/j.omtm.2017.02.003

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