Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral Vectors

16 Mar 2019

Abstract excerpt

Chimeric antigen receptor (CAR)-modified T cells have revealed promising results in the treatment of cancer, but they still need to overcome various hurdles, including a complicated manufacturing process. Receptor-targeted lentiviral vectors (LVs) delivering genes selectively to T cell subtypes may facilitate and improve CAR T cell generation, but so far they have resulted in lower gene delivery rates than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30997367
DOI: 10.1016/j.omtm.2019.03.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral VectorsPMID 30997367Read ↗

Vectofusin-1–based T-cell transduction approach compared with RetroNectin-based transduction for generating murine chimeric antigen receptor T-cellsSemantic proximity Read ↗

Production of CAR T-cells by GMP-grade lentiviral vectors: latest advances and future prospectsSemantic proximity Read ↗

In Vivo Generation of CAR T Cells Selectively in Human CD4+ LymphocytesSemantic proximity Read ↗

Design and Characterization of an “All-in-One” Lentiviral Vector System Combining Constitutive Anti-GD2 CAR Expression and Inducible CytokinesSemantic proximity Read ↗

Enhanced lentiviral gene delivery to mammalian cells via paired cell surface and viral envelope engineeringSemantic proximity Read ↗

Optimization of electroporation and other non‐viral gene delivery strategies for T cellsSemantic proximity Read ↗

Effects of polybrene and retronectin as transduction enhancers on the development and phenotypic characteristics of VHH-based CD19-redirected CAR T cells: a comparative investigation.Semantic proximity Read ↗

Efficient in vivo generation of CAR T cells using a retargeted fourth-generation lentiviral vectorSemantic proximity Read ↗

Design and implementation of adoptive therapy with chimeric antigen receptor‐modified T cellsSemantic proximity Read ↗

Physiological (TCR-like) regulated lentiviral vectors for the generation of improved CAR-T cellsSemantic proximity Read ↗

Progress in Pseudotyping Lentiviral Vectors Towards Cell-Specific Gene Delivery In VivoSemantic proximity Read ↗

Combining T-cell-specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.