Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DJ-1 protects against cell death following acute cardiac ischemia–reperfusion injury

27 Feb 2014

Abstract excerpt

Novel therapeutic targets are required to protect the heart against cell death from acute ischemia-reperfusion injury (IRI). Mutations in the DJ-1 (PARK7) gene in dopaminergic neurons induce mitochondrial dysfunction and a genetic form of Parkinson's disease. Genetic ablation of DJ-1 renders the brain more susceptible to cell death following ischemia-reperfusion in a model of stroke. Although DJ-1 is present in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroscience and Neural Engineering
Share to Neuroscience and Neuropharmacology Research
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24577080
DOI: 10.1038/cddis.2014.41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DJ-1 protects against cell death following acute cardiac ischemia–reperfusion injuryPMID 24577080Read ↗

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damageSemantic proximity Read ↗

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.Semantic proximity Read ↗

Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo.Semantic proximity Read ↗

Parkinson's disease proteins: Novel mitochondrial targets for cardioprotectionSemantic proximity Read ↗

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.Semantic proximity Read ↗

Mitochondrial Approaches to Protect Against Cardiac Ischemia and Reperfusion InjurySemantic proximity Read ↗

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition.Semantic proximity Read ↗

The DJ-1-derived peptide, ND-13, confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1 pathwaySemantic proximity Read ↗

DJ-1 has a role in antioxidative stress to prevent cell death.Semantic proximity Read ↗

DJ-1 regulation of mitochondrial function and autophagy through oxidative stressSemantic proximity Read ↗

Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial InfarctionSemantic proximity Read ↗

Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.