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Article

p62/ SQSTM1 and Selective Autophagy in Cardiometabolic Diseases

27 Dec 2018

Abstract excerpt

Significance: p62/SQSTM1 is a multifunctional scaffolding protein involved in the regulation of various signaling pathways as well as autophagy. In particular, p62/SQSTM1 serves as an essential adaptor to identify and deliver specific organelles and protein aggregates to autophagosomes for degradation, a process known as selective autophagy. Critical Issues: With the emergence of autophagy as a critical process...

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PMID: 30588824
DOI: 10.1089/ars.2018.7649

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