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Article

Protumorigenic Role of HAPLN1 and Its IgV Domain in Malignant Pleural Mesothelioma

8 Apr 2009

Abstract excerpt

PURPOSE: Tumor extracellular matrix (ECM) plays a crucial role in cancer progression mediating and transforming host-tumor interactions. Targeting the ECM is becoming an increasingly promising therapeutic approach in cancer treatment. We find that one of the ECM proteins, HAPLN1, is overexpressed in the majority of mesotheliomas. This study was designed to characterize the protumorigenic role of HAPLN1 in...

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PMID: 19351750
DOI: 10.1158/1078-0432.ccr-08-2755

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