Article

Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting Enteropathy

2020-10-12

Abstract excerpt

<h4>Background & Aims</h4> Congenital Tufting Enteropathy (CTE) is an intractable diarrheal disease of infancy caused by mutation of Epithelial Cell Adhesion Molecule (EpCAM). The cellular and molecular basis of CTE pathology has been elusive. We hypothesized that the loss of EpCAM in CTE results in altered lineage differentiation and defects in absorptive enterocytes thereby contributing to CTE pathogenesis. <h4...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9422b342-126c-5490-851d-b96ac44f43bc
DOI: 10.1101/2020.10.12.330522

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting EnteropathyDOI 10.1101/2020.10.12.330522Read

Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting Enteropathy.Semantic proximity Read

Novel Mutations in EPCAM Cause Congenital Tufting Enteropathy.Semantic proximity Read

Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction.Semantic proximity Read

The role of enterocyte defects in the pathogenesis of congenital diarrheal disorders.Semantic proximity Read

Case Series of Eight Congenital Tufting Enteropathy Patients and Literature Review.Semantic proximity Read

The genetics of monogenic intestinal epithelial disorders.Semantic proximity Read

Dclk1-expressing tuft cells: critical modulators of the intestinal niche?Semantic proximity Read

The intestinal epithelium tuft cells: specification and functionSemantic proximity Read

Unraveling Enteroendocrine Cell lineage dynamics and associated gene regulatory networks during intestinal developmentSemantic proximity Read

Functional consequences of EpCam mutation in mice and men.Semantic proximity Read

Genetic characterization of congenital tufting enteropathy: epcam associated phenotype and involvement of SPINT2 in the syndromic form.Semantic proximity Read

Emc3 maintains intestinal homeostasis by preserving secretory lineagesSemantic proximity Read