Article
Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting Enteropathy.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2021
Das Barun, Okamoto Kevin, Rabalais John, Young Jocelyn A, Barrett Kim E, Sivagnanam Mamata
Abstract excerpt
BACKGROUND & AIMS: Congenital tufting enteropathy (CTE) is an intractable diarrheal disease of infancy caused by mutations of epithelial cell adhesion molecule (EpCAM). The cellular and molecular basis of CTE pathology has been elusive. We hypothesized that the loss of EpCAM in CTE results in altered lineage differentiation and defects in absorptive enterocytes thereby contributing to CTE pathogenesis. METHODS:...
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