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Article

Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction.

Journal of molecular medicine (Berlin, Germany) - 1 May 2015

Kozan Philip A, McGeough Matthew D, Peña Carla A, Mueller James L, Barrett Kim E, Marchelletta Ronald R, Sivagnanam Mamata

Abstract excerpt

UNLABELLED: Congenital tufting enteropathy (CTE) is a devastating diarrheal disease seen in infancy that is typically associated with villous changes and the appearance of epithelial tufts. We previously found mutations in epithelial cell adhesion molecule (EpCAM) to be causative in CTE. We developed a knock-down cell model of CTE through transfection of an EpCAM shRNA construct into T84 colonic epithelial cells...

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Topics

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Share to Antigens, Neoplasm
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Knockdown Techniques

Share to Intestinal Mucosa

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Share to RNA, Small Interfering

Source

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Identifiers

PMID: 25482158
DOI: 10.1007/s00109-014-1239-x
PMCID: PMC4408367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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