Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53.

Nucleic acids research - 15 Nov 2001

Sugars K L, Budhram-Mahadeo V, Packham G, Latchman D S

Abstract excerpt

The Brn-3a transcription factor stimulates the expression of the anti-apoptotic Bcl-2 and Bcl-x proteins and protects neuronal cells from apoptosis. Here we show that a minimal Bcl-x promoter is activated by Brn-3a and that this stimulation is prevented by the pro-apoptotic p53 protein. Both these effects are mediated via Bcl-x promoter sequences, which are indistinguishable from those required for minimal basal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-X Protein
Share to Genetic Vectors
Share to Luciferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-bcl-2

Share to Recombinant Fusion Proteins

Share to Thymidine Kinase

Share to Transfection

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 11713302
DOI: 10.1093/nar/29.22.4530
PMCID: PMC92563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53.PMID 11713302Read ↗

Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.Semantic proximity Read ↗

Brn-3a Transcription Factor Blocks p53-mediated Activation of Proapoptotic Target Genes Noxa and Bax in Vitro and in Vivo to Determine Cell FateSemantic proximity Read ↗

Pro-apoptotic Bim induction in response to nerve growth factor deprivation requires simultaneous activation of three different death signaling pathways.Semantic proximity Read ↗

Bim Is a Direct Target of a Neuronal E2F-Dependent Apoptotic PathwaySemantic proximity Read ↗

Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x geneSemantic proximity Read ↗

A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genesSemantic proximity Read ↗

FOXO transcription factors directly activate <i>bim</i> gene expression and promote apoptosis in sympathetic neuronsSemantic proximity Read ↗

p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter.Semantic proximity Read ↗

A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoter.Semantic proximity Read ↗

A Negative Regulatory Element in the <i>bcl-2</i> 5'-Untranslated Region Inhibits Expression from an Upstream PromoterSemantic proximity Read ↗

Heterogeneous Nuclear Ribonucleoprotein F/H Proteins Modulate the Alternative Splicing of the Apoptotic Mediator Bcl-xSemantic proximity Read ↗

The Putative Oncoprotein Bcl-3 Induces Cyclin D1 To Stimulate G<sub>1</sub> TransitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.