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Surface architecture of the bacterial envelope determines phage adsorption route in pathogenic Escherichia coli O157:H7

2026-07-24

Abstract excerpt

The outermost surface layers of Gram-negative bacteria determine phage access to terminal receptors, yet their genetic basis has been mapped almost exclusively in laboratory strains that lack them. Here we apply genome-wide RB-TnSeq fitness profiling to four Escherichia coli O157:H7 strains from distinct phylogenetic clades sharing the O157 O-antigen, using 38 phages with terminal receptors previously mapped in...

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Literature Corpus work: 93b26fe9-61a7-5b2b-b311-166562ff8276
DOI: 10.64898/2026.07.23.740414

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Surface architecture of the bacterial envelope determines phage adsorption route in pathogenic <i>Escherichia coli</i> O157:H7

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