Article
Characterization of a Protective Monoclonal AntibodyRecognizing <i>Staphylococcus aureus</i> MSCRAMM ProteinClumping FactorA
25 Nov 2003
Abstract excerpt
The Staphylococcus aureus MSCRAMM (microbial surface components recognizing adhesive matrix molecules) protein clumping factor A (ClfA) has been shown to be a critical virulence factor in several experimental models of infection. This report describes the generation, characterization, and in vivo evaluation of a murine monoclonal antibody (MAb) against ClfA. Flow cytometric analysis revealed that MAb 12-9...
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