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Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB

14 Jun 2012

Abstract excerpt

Staphylococcus aureus (S. aureus) pathogenesis is a complex process involving a diverse array of extracellular and cell wall components. ClfB, an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules) family surface protein, described as a fibrinogen-binding clumping factor, is a key determinant of S. aureus nasal colonization, but the molecular basis for ClfB-ligand recognition remains...

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PMID: 22719251
DOI: 10.1371/journal.ppat.1002751

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