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Article

The interaction of the atm genotype with inflammation and oxidative stress.

PloS one - 1 Jan 2014

Yang Yan, Hui Chin Wai, Li Jiali, Herrup Karl

Abstract excerpt

In ataxia-telangiectasia (A-T) the death of neurons is associated with the loss of neuronal cell cycle control. In most Atm(-/-) mouse models, however, these cell cycle anomalies are present but the phenotype of neuronal cell loss found in humans is not. Mouse Atm(-/-) neurons re-enter a cell cycle and replicate their DNA, but they do not die--even months after initiating the cycle. In the current study, we...

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Source

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Identifiers

PMID: 24465754
DOI: 10.1371/journal.pone.0085863
PMCID: PMC3896418

Genes

ATM
HDAC4
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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The interaction of the atm genotype with inflammation and oxidative stress.PMID 24465754Read ↗

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