Article

Transient RNA structures underlie highly pathogenic avian influenza virus genesis

2024-01-11

Abstract excerpt

Highly pathogenic avian influenza viruses (HPAIVs) cause severe disease and high fatality in poultry 1 . They emerge exclusively from H5 and H7 low pathogenic avian influenza viruses (LPAIVs) 2 . Although insertion of a furin-cleavable multibasic cleavage site (MBCS) in the hemagglutinin gene was identified decades ago as the genetic basis for LPAIV-to-HPAIV transition 3,4 , the exact mechanisms underlying said...

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Literature Corpus work: 936a301f-71e0-5e3c-b26d-8b6d90e50797
DOI: 10.1101/2024.01.11.574333

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