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Genetic Predisposition To Acquire a Polybasic Cleavage Site for Highly Pathogenic Avian Influenza Virus Hemagglutinin.

mBio - 14 Feb 2017

Nao Naganori, Yamagishi Junya, Miyamoto Hiroko, Igarashi Manabu, Manzoor Rashid, Ohnuma Aiko, Tsuda Yoshimi, Furuyama Wakako, Shigeno Asako, Kajihara Masahiro, Kishida Noriko, Yoshida Reiko, Takada Ayato

Abstract excerpt

Highly pathogenic avian influenza viruses with H5 and H7 hemagglutinin (HA) subtypes evolve from low-pathogenic precursors through the acquisition of multiple basic amino acid residues at the HA cleavage site. Although this mechanism has been observed to occur naturally only in these HA subtypes, little is known about the genetic basis for the acquisition of the polybasic HA cleavage site. Here we show that...

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Identifiers

PMID: 28196963
DOI: 10.1128/mBio.02298-16
PMCID: PMC5312086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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