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Article

Conserved structural RNA domains in regions coding for cleavage site motifs in hemagglutinin genes of influenza viruses

1 Jul 2019

Abstract excerpt

The acquisition of a multibasic cleavage site (MBCS) in the hemagglutinin (HA) glycoprotein is the main determinant of the conversion of low pathogenic avian influenza viruses into highly pathogenic strains, facilitating HA cleavage and virus replication in a broader range of host cells. In nature, substitutions or insertions in HA RNA genomic segments that code for multiple basic amino acids have been observed...

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PMID: 31456885
DOI: 10.1093/ve/vez034

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