Article
Malignant function of nuclear factor-kappaB axis in prostate cancer: Molecular interactions and regulation by non-coding RNAs.
Pharmacological research - 1 Aug 2023
Al-Rashidi Reyadh R, Noraldeen Sara Abdalrazzaq M, Kareem Ali Kamil, Mahmoud Aisha Kamal, Kadhum Wesam R, Ramírez-Coronel Andrés Alexis, Iswanto Acim Heri, Obaid Rasha Fadhel, Jalil Abduladheem Turki, Mustafa Yasser Fakri, Nabavi Noushin, Wang Yuzhuo, Wang Lin
Abstract excerpt
Prostate carcinoma is a malignant situation that arises from genomic alterations in the prostate, leading to changes in tumorigenesis. The NF-κB pathway modulates various biological mechanisms, including inflammation and immune responses. Dysregulation of NF-κB promotes carcinogenesis, including increased proliferation, invasion, and therapy resistance. As an incurable disease globally, prostate cancer is a...
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