Article

Inhibition of Androgen Receptor Signaling Reduces Inflammation in the Lung with SARS-CoV-2 Infection Through Dampening IL6 Signaling

2022-07-19

Abstract excerpt

Dissecting the mechanism of the inflammatory response to SARS-CoV-2 infection is critical for establishing therapeutic options. Increased mortality associated with COVID-19 in male patients could be orchestrated through the androgen receptor (AR) signaling and activation of the immune response. We report a direct link between AR signaling and interleukin 6 (IL6) expression through AR antagonist, enzalutamide, and...

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Literature Corpus work: 81683428-407d-5f9a-8bf3-17736ad6690a
DOI: 10.2139/ssrn.4161717

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