Article

Neural-symbolic hybrid model for myosin complex in cardiac ventriculum decodes structural bases for inheritable heart disease from its genetic encoding

2024-09-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Human ventriculum myosin (βmys) powers contraction sometimes in complex with myosin binding protein C (MYBPC3). The latter regulates βmys activity and impacts overall cardiac function. Nonsynonymous single nucleotide variants (SNVs) change protein sequence in βmys or MYBPC3 causing inheritable heart diseases by affecting the βmys/MYBPC3 complex. Muscle genetics encode instru...

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Literature Corpus work: 69fa7a14-270e-5eea-9a3d-d79ac3e4be39
DOI: 10.1101/2024.09.05.611508

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