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Article

Dynamics of genome evolution in the era of pangenome analysis.

Cell genomics - 14 Jan 2026

Loegler Victor, Friedrich Anne, Schacherer Joseph

Abstract excerpt

The advent of long-read sequencing and telomere-to-telomere (T2T) assemblies has transformed studies of eukaryotic genomic variation. Pangenomes now leverage these advances to generate comprehensive catalogs of structural variants (SVs) and gene presence-absence polymorphisms across populations. Here, we review how pangenomes improve the identification, classification, and large-scale analysis of SVs and gene...

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Identifiers

PMID: 41260225
DOI: 10.1016/j.xgen.2025.101067
PMCID: PMC12926196

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