Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in 3D-spheroids model of platinum-resistant ovarian cancer

Abstract excerpt

<title>Abstract</title> <p>Ovarian cancer follows a characteristic progression pattern, forming multiple tumor masses enriched with cancer stem cells (CSCs) within the abdomen. Most patients develop resistance to standard platinum-based drugs, necessitating better treatment approaches. To target CSCs, inhibition of nicotinamide phosphoribosyltransferase (NAMPT), which is the rate-limiting enzyme in the salvage pa...

Topics

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• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Cancer Mechanisms and Therapy
• Epigenetics and DNA Methylation
• Histone Deacetylase Inhibitors Research
• Microtubule and mitosis dynamics
• PARP inhibition in cancer therapy
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

92da75b6-119e-58f1-ad4c-3896f800c4f0

DOI

10.21203/rs.3.rs-3399502/v1