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Divergent metabolic responses dictate vulnerability to NAMPT inhibition in ovarian cancer

17 Jan 2020

Abstract excerpt

It is of current interest to target cancer metabolism as treatment for many malignancies, including ovarian cancer (OVC), in which few druggable driver mutations have been identified. Nicotinamide phosphoribosyltransferase (NAMPT), a rate-limiting enzyme in the NAD salvage pathway, is a potential therapeutic target in OVC. However, factors that determine responsiveness to NAMPT inhibition are not fully...

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PMID: 31950503
DOI: 10.1002/1873-3468.13736

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