Article

Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers

2024-12-08

Abstract excerpt

Inflammatory bowel disease (IBD) patients exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis, and cancer risk, with symptoms often being exacerbated in women during pregnancy. Here, we show that these IBD hallmarks can be replicated using human Organ Chips lined by IBD patient-derived colon epithelial cells interfaced with matched fibroblas...

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Literature Corpus work: 5ef55681-bd59-546d-85c7-86b7fb1a7c23
DOI: 10.1101/2024.12.05.24318563

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