Article

Mutational signatures in cancer genomes alter protein sequence motifs in cellular signaling networks

2026-02-05

Abstract excerpt

Somatic mutations in cancer genomes arise from distinct, context-specific mutational processes, yet their functional consequences at the protein and network level remain incompletely understood. Here, we show that mutational processes of single-nucleotide variants (SNVs) can systematically rewire signaling networks by inducing amino acid substitutions in short linear motifs (SLiMs) that mediate interactions with k...

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Literature Corpus work: 92b66976-e027-5372-a9ba-2a6ef476c90b
DOI: 10.64898/2026.02.03.703397

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