Article

<i>Bcl-2</i> homologue <i>debcl</i> enhances <i>α-synuclein</i> -induced phenotypes in Drosophila

2016-05-04

Abstract excerpt

<h4>Background: </h4> Parkinson disease (PD) is a debilitating movement disorder that afflicts 1 to 2% of the population over 50 years of age. The common hallmark for both sporadic and familial forms of PD is mitochondrial dysfunction. Mammals have at least twenty proapoptotic and antiapoptotic Bcl-2 family members, in contrast, only two Bcl-2 family genes have been identified in Drosophila melanogaster, the pro...

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Literature Corpus work: 929ad45a-e483-5f8e-89cf-fddafe2922f5
DOI: 10.7287/peerj.preprints.2025v1

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