Article

Altered Parkin and Bcl-2 Expression Suppresses Drp1 Gain and Loss of Function Age-Related Phenotypes in Drosophila

2024-07-16

Abstract excerpt

The relationship of Amyotrophic Lateral Sclerosis, Parkinson Disease and other age-related neurodegenerative diseases associated with mitochondrial dysfunction has led to study of the mitochondrial fission gene Drp1 in Drosophila. Drp1 can interact with mitochondrial proteins including parkin and the Drosophila Bcl-2 proteins. Mutations in Drp1 can lead to mitochondrial dysfunction and neuronal loss. Ddc-Gal4 was...

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Literature Corpus work: 69b961d9-4f7f-51c0-b873-53bb70c03b70
DOI: 10.20944/preprints202407.1258.v1

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