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Bcl-2 Orthologues, Buffy and Debcl, Can Suppress Drp1-Dependent Age-Related Phenotypes in Drosophila.

Biomolecules - 30 Aug 2024

Hasan Azra, Staveley Brian E

Abstract excerpt

The relationship of Amyotrophic Lateral Sclerosis, Parkinson's disease, and other age-related neurodegenerative diseases with mitochondrial dysfunction has led to our study of the mitochondrial fission gene Drp1 in Drosophila melanogaster and aspects of aging. Previously, the Drp1 protein has been demonstrated to interact with the Drosophila Bcl-2 mitochondrial proteins, and Drp1 mutations can lead to...

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PMID: 39334855
DOI: 10.3390/biom14091089
PMCID: PMC11429860

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Bcl-2 Orthologues, Buffy and Debcl, Can Suppress Drp1-Dependent Age-Related Phenotypes in Drosophila.PMID 39334855Read ↗

Altered Parkin and Bcl-2 Expression Suppresses Drp1 Gain and Loss of Function Age-Related Phenotypes in DrosophilaSemantic proximity Read ↗

Overexpression of Buffy enhances the loss of parkin and suppresses the loss of Pink1 phenotypes in Drosophila.Semantic proximity Read ↗

<i>Bcl-2</i> homologue <i>debcl</i> enhances <i>α-synuclein</i> -induced phenotypes in DrosophilaSemantic proximity Read ↗

The Bcl-2 homologue Buffy rescues α-synuclein-induced Parkinson disease-like phenotypes in Drosophila.Semantic proximity Read ↗

The HtrA2 Drosophila model of Parkinson's disease is suppressed by the pro-survival Bcl-2 Buffy.Semantic proximity Read ↗

<i>Bax-inhibitor-1</i> loss of function phenotypes are suppressed by <i>Buffy</i> in <i>Drosophila</i>Semantic proximity Read ↗

Alteration of Drp1 Expression in Drosophila Models of Parkinson DiseaseSemantic proximity Read ↗

The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death.Semantic proximity Read ↗

Inhibition of Ref(2)P, the Drosophila homologue of the p62/SQSTM1 gene, increases lifespan and leads to a decline in motor function Semantic proximity Read ↗

Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypesSemantic proximity Read ↗

Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant.Semantic proximity Read ↗

Inhibition of Atg6 and Pi3K59F autophagy genes in neurons decreases lifespan and locomotor ability in Drosophila melanogasterSemantic proximity Read ↗

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