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Article

The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death.

Development (Cambridge, England) - 1 Jan 2009

Galindo Kathleen A, Lu Wan-Jin, Park Jae H, Abrams John M

Abstract excerpt

Bcl-2 family members are pivotal regulators of programmed cell death (PCD). In mammals, pro-apoptotic Bcl-2 family members initiate early apoptotic signals by causing the release of cytochrome c from the mitochondria, a step necessary for the initiation of the caspase cascade. Worms and flies do not show a requirement for cytochrome c during apoptosis, but both model systems express pro- and anti-apoptotic Bcl-2...

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Identifiers

PMID: 19088092
DOI: 10.1242/dev.019042
PMCID: PMC2685970

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