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Article

Population pharmacokinetic modeling and Monte Carlo simulation-based dosing optimization of trimethoprim-sulfamethoxazole in critically ill patients.

European journal of clinical pharmacology - 31 Mar 2026

Wang Min, Li Chen, Fu Xiangxiang, Wang Fangling, Zhou Xiaojun, Zhang Bingli, Xu Wenya, Liang Liqiu, Lei Zhenlin, Qu Hengxing, Xie Ling, Zhong Lili, Zheng Yuanyuan, Liu Tao

Abstract excerpt

OBJECTIVE: This study aimed to establish a population pharmacokinetic (PPK) model of trimethoprim-sulfamethoxazole (TMP/SMZ) in critically ill patients from Hainan, to identify key determinants of drug exposure, and to provide a basis for individualized dosing optimization. METHODS: Twenty-eight ICU patients receiving TMP/SMZ therapy were enrolled. Plasma concentrations of TMP, SMZ, and the metabolite...

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Share to Anti-Bacterial Agents
Share to Arylamine N-Acetyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Critical Illness

Share to Cytochrome P-450 CYP2C9

Share to Dose-Response Relationship, Drug

Share to Models, Biological

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Share to Trimethoprim, Sulfamethoxazole Drug Combination

Source

Identifiers

PMID: 41912902
DOI: 10.1007/s00228-026-04019-5

Genes

CYP2C9
BID
GCLC
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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