Article

Beyond Student’s t: A Systematic Exploration of Heavy-Tailed Residual Densities for Outlier Handling in Population PK Modeling

2026-03-03

Abstract excerpt

<h4>Background</h4> Reliable population pharmacokinetic (PopPK) parameter estimation can be compromised by outliers under Gaussian residual error models. A common mitigation strategy is post hoc filtering based on conditional weighted residuals (CWRES); however, this approach can be insensitive due to model “masking” driven by variance inflation. Practical barriers to implementing robust likelihoods in standard s...

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Literature Corpus work: 1fe7e4b6-1fd4-5aee-9449-1570490137d4
DOI: 10.64898/2026.03.01.708825

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