Article

Group Testing Can Improve the Cost-Efficiency of Prospective-Retrospective Biomarker Studies

2021-01-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Cancer treatment is increasingly dependent on biomarkers for prognostication and treatment selection. Potential biomarkers are frequently evaluated in prospective-retrospective studies in which biomarkers are measured retrospectively on archived specimens after completion of prospective clinical trials. In light of the high costs of some assays, random sampling...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92278267-d1d0-547f-b091-85e740933ab9
DOI: 10.21203/rs.3.rs-51687/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Group Testing Can Improve the Cost-Efficiency of Prospective-Retrospective Biomarker StudiesDOI 10.21203/rs.3.rs-51687/v2Read

Prospective–Retrospective Biomarker Analysis for Regulatory Consideration: white Paper from the Industry Pharmacogenomics Working GroupSemantic proximity Read

Optimal DNA pooling-based two-stage designs in case-control association studies.Semantic proximity Read

Randomized clinical trials with biomarkers: design issues.Semantic proximity Read

Logistic regression analysis of biomarker data subject to pooling and dichotomization.Semantic proximity Read

A hierarchical Bayes model for biomarker subset effects in clinical trialsSemantic proximity Read

Research issues and strategies for genomic and proteomic biomarker discovery and validation: a statistical perspective.Semantic proximity Read

Quantifying Treatment Benefit in Molecular Subgroups to Assess a Predictive Biomarker.Semantic proximity Read

Two-stage group sequential robust tests in family-based association studies: controlling type I error.Semantic proximity Read

Goodness-of-fit two-phase sampling designs for time-to-event outcomes: a simulation study based on New York University Women’s Health Study for breast cancerSemantic proximity Read

Optimal multistage designs--a general framework for efficient genome-wide association studies.Semantic proximity Read

Analysis of SNPs in pooled DNA: a decision theoretic model.Semantic proximity Read

Group additive regression models for genomic data analysis.Semantic proximity Read