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Article

Randomized clinical trials with biomarkers: design issues.

Journal of the National Cancer Institute - 3 Feb 2010

Freidlin Boris, McShane Lisa M, Korn Edward L

Abstract excerpt

Clinical biomarker tests that aid in making treatment decisions will play an important role in achieving personalized medicine for cancer patients. Definitive evaluation of the clinical utility of these biomarkers requires conducting large randomized clinical trials (RCTs). Efficient RCT design i...

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Identifiers

PMID: 20075367
DOI: 10.1093/jnci/djp477
PMCID: PMC2911042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20075367-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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