Article

Brain-targeted PROTAC delivery by dual-functional extracellular vesicles achieves robust LRRK2 degradation in a Parkinson’s disease model

2026-02-24

Abstract excerpt

<title>Abstract</title> Mesenchymal stem cell–derived extracellular vesicles (MSC-EVs) have emerged as promising therapeutic delivery vehicles for brain diseases. However, their limited ability to cross the blood–brain barrier (BBB) remains a major obstacle to clinical translation. To overcome this limitation, we designed a multifunctional peptide consisting of a membrane-anchoring transmembrane domain (TD) an...

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Literature Corpus work: 9221468a-3559-5c72-a01f-59909e6e1ed9
DOI: 10.21203/rs.3.rs-8830833/v1

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