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Article

Long-term hematopoietic stem cells as a parasite niche during treatment failure in visceral leishmaniasis

25 Jun 2022

Abstract excerpt

Given the discontinuation of various first-line drugs for visceral leishmaniasis (VL), large-scale in vivo drug screening, establishment of a relapse model in rodents, immunophenotyping, and transcriptomics were combined to study persistent infections and therapeutic failure. Double bioluminescent/fluorescent Leishmania infantum and L. donovani reporter lines enabled the identification of long-term hematopoietic...

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PMID: 35752645
DOI: 10.1038/s42003-022-03591-7

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