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Article

Rev1-Rev7 Complex Inhibitor JH-RE-06 Enhances Mitomycin C Chemosensitivity in HCT116 Colorectal Cancer Cells

2023-06-27

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Cancer cells can develop resistance to DNA interstrand crosslinker agents through a DNA repair bypass pathway called TLS. JH-RE-06, a TLS-targeting inhibitor, has been shown to increase melanoma cell susceptibility to cisplatin. Nevertheless, whether JH-RE-06 can be used in combination with Mitomycin C (MMC) to benefit Colorectal Cancer (CRC) patients receiving...

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Literature Corpus work
921c1a14-0e54-507b-8944-fb7baf8668b6
DOI
10.21203/rs.3.rs-3071400/v1
Open publication

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Rev1-Rev7 Complex Inhibitor JH-RE-06 Enhances Mitomycin C Chemosensitivity in HCT116 Colorectal Cancer CellsDOI 10.21203/rs.3.rs-3071400/v1
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