Article
A pH-eQTL interaction at the RIT2-SYT4 Parkinson’s disease risk locus in the substantia nigra
2020-12-16
Abstract excerpt
Parkinson’s disease (PD) causes severe motor and cognitive disabilities that result from the progressive loss of dopamine neurons in the substantia nigra. The rs12456492 variant in the RIT2 gene has been repeatedly associated with increased risk for Parkinson’s disease. From a transcriptomic perspective, a meta-analysis found that RIT2 gene expression is correlated with pH in the human brain. To assess these pH a...
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Identifiers and source
- Literature Corpus work
- 91c43825-0cf8-53fa-896a-819a4c9e3002
- DOI
- 10.1101/2020.12.16.423140