Article

First-in-Human Study of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix

2025-10-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Antibodies against the SARS-CoV-2 spike receptor-binding domain provided effective COVID-19 treatment until resistant variants emerged. GB-0669 is a half-life extended monoclonal antibody optimized using artificial intelligence, targeting the conserved spike S2 stem helix, a region with limited selective pressure from natural infection-or vaccine-induced antibody responses....

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Literature Corpus work: 91bc68b8-9c9b-5549-84ca-4069baed5281
DOI: 10.1101/2025.10.07.25337449

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