Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MAP Kinase-Interacting Kinase 1 Regulates SMAD2-Dependent TGF-β Signaling Pathway in Human Glioblastoma

14 Mar 2011

Abstract excerpt

Glioblastoma multiforme (GBM) is the most common aggressive brain cancer with a median survival of approximately 1 year. In a search for novel molecular targets that could be therapeutically developed, our kinome-focused microarray analysis identified the MAP (mitogen-activated protein) kinase-interacting kinase 1 (MNK1) as an attractive theranostic candidate. MNK1 overexpression was confirmed in both primary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to PI3K/AKT/mTOR signaling in cancer
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21406405
DOI: 10.1158/0008-5472.can-10-3112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MAP Kinase-Interacting Kinase 1 Regulates SMAD2-Dependent TGF-β Signaling Pathway in Human GlioblastomaPMID 21406405Read ↗

Molecular mechanisms of the effect of TGF-β1 on U87 human glioblastoma cellsSemantic proximity Read ↗

Up-regulation of miR-663a inhibits the cancer stem cell-like properties of glioma via repressing the KDM2A-mediated TGF-β/SMAD signaling pathwaySemantic proximity Read ↗

Cyclin-dependent kinase subunit2 (CKS2) promotes malignant phenotypes and epithelial-mesenchymal transition-like process in glioma by activating TGFβ/SMAD signaling.Semantic proximity Read ↗

MICAL2 Promotes Proliferation and Migration of Glioblastoma Cells Through TGF-β/p-Smad2/EMT-Like Signaling PathwaySemantic proximity Read ↗

Intronic miR-744 Inhibits Glioblastoma Migration by Functionally Antagonizing Its Host Gene MAP2K4Semantic proximity Read ↗

RUNX1 contributes to the mesenchymal subtype of glioblastoma in a TGFβ pathway-dependent mannerSemantic proximity Read ↗

IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling pathway in Glioblastoma multiforme cellsSemantic proximity Read ↗

Multiplex-inhibitor bead mass spectrometry reveals differential kinome signatures in newly diagnosed and recurrent glioblastomaSemantic proximity Read ↗

Targeting NF-κB in glioblastoma: A therapeutic approachSemantic proximity Read ↗

PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastomaSemantic proximity Read ↗

NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma.Semantic proximity Read ↗

PDGF-R inhibition induces glioblastoma cell differentiation via DUSP1/p38MAPK signallingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.