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Comprehensive analysis of the role of ICOS ( CD278 ) in pan-cancer prognosis and immunotherapy

28 Feb 2023

Abstract excerpt

BACKGROUND: The immunological checkpoint known as Inducible T Cell Costimulatory Factor (ICOS, Cluster of Differentiation, CD278) is activated and expressed on T cells. Both somatic cells and antigen-presenting cells expressed its ligand, ICOSL (including tumor cells in the tumor microenvironment).It is important for immunosuppression. Uncertainty surrounds the function of ICOS in tumor immunity. METHODS: Several...

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PMID: 36855091
DOI: 10.1186/s12885-023-10564-4

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