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Article

CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.

Cell death & disease - 16 Feb 2022

Ruan Yu, Hu Jiaqiao, Che Yaping, Liu Yanyan, Luo Zhenhuan, Cheng Jin, Han Qi, He He, Zhou Qinghua

Abstract excerpt

Mitochondrial dysfunction is becoming one of the main pathology factors involved in the etiology of neurological disorders. Recently, mutations of the coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and 10 (CHCHD10) which encode two homologous proteins that belong to the mitochondrial CHCH domain protein family, are linked to Parkinson's disease and amyotrophic lateral sclerosis...

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Identifiers

PMID: 35173147
DOI: 10.1038/s41419-022-04602-5
PMCID: PMC8850591

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