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Article

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.

The Journal of experimental medicine - 14 Feb 2011

Okazaki Taku, Okazaki Il-mi, Wang Jian, Sugiura Daisuke, Nakaki Fumio, Yoshida Taku, Kato Yu, Fagarasan Sidonia, Muramatsu Masamichi, Eto Tomoo, Hioki Kyoji, Honjo Tasuku

Abstract excerpt

Stimulatory and inhibitory co-receptors play fundamental roles in the regulation of the immune system. We describe a new mouse model of spontaneous autoimmune disease. Activation-induced cytidine deaminase-linked autoimmunity (aida) mice harbor a loss-of-function mutation in the gene encoding lymphocyte activation gene 3 (LAG-3), an inhibitory co-receptor. Although LAG-3 deficiency alone did not induce...

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Identifiers

PMID: 21300912
DOI: 10.1084/jem.20100466
PMCID: PMC3039848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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