Article

Genomic Drug Resistance Biomarkers in Leishmania infantum: from Quantitative Real- Time PCR (qPCR) to digital PCR (dPCR)

2026-06-22

Abstract excerpt

<title>Abstract</title> Background The treatment outcome of canine leishmaniosis (CanL) may be influenced by drug resistance. Gene copy number variations (CNVs) within the <italic>metk</italic> , <italic>mrpa</italic> , and <italic>LdMT</italic> genes of <italic>Leishmania infantum</italic> have been described as Genomic Drug Resistance Biomarkers (GDRB). Present quantitative real-time PCR (qPCR) me...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9174e663-f01d-59da-abeb-591b2ca3e7cb
DOI: 10.21203/rs.3.rs-10009392/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic Drug Resistance Biomarkers in Leishmania infantum: from Quantitative Real- Time PCR (qPCR) to digital PCR (dPCR)DOI 10.21203/rs.3.rs-10009392/v1Read

Direct quantitative PCR detects genetic biomarkers of antileishmanial drug resistance in clinical samples from dogs with leishmaniosisSemantic proximity Read

Insights on genomic profiles of drug resistance and virulence in a cohort of Leishmania infantum isolates from the Mediterranean areaSemantic proximity Read

Identification of Leishmania infantum Epidemiology, Drug Resistance and Pathogenicity Biomarkers with Nanopore SequencingSemantic proximity Read

Measurement of gene amplifications related to drug resistance in Plasmodium falciparum using droplet digital PCRSemantic proximity Read

Tracking the Spread of a Naturally Occurring Leishmania infantum Mutant: A qPCR-Based Investigation in Strains and Clinical SamplesSemantic proximity Read

Antimalarial resistance risk in Mozambique detected by a novel quadruplex droplet digital PCR assaySemantic proximity Read

Unravelling drug resistance in leishmaniasis: genomic adaptations and emerging therapiesSemantic proximity Read

Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy numberSemantic proximity Read

Measurement of gene amplifications related to drug resistance in Plasmodium falciparum using droplet digital PCRSemantic proximity Read

Droplet digital PCR as a tool to detect resistant isolates of Dirofilaria immitisSemantic proximity Read

Digital PCR: modern solution to parasite diagnostics and population trait genetics.Semantic proximity Read