Back to search

Article

Tracking the Spread of a Naturally Occurring <i>Leishmania infantum</i> Mutant: A qPCR-Based Investigation in Strains and Clinical Samples

2025-08-22

Abstract excerpt

The circulation of Leishmania infantum strains carrying a 12 Kb genomic deletion (DEL) alongside wild-type (NonDEL) parasites in the Americas raises critical epidemiological questions. To support molecular surveillance efforts, we developed and validated a qPCR-based genotyping tool capable of detecting and quantifying DEL, NonDEL, and coinfection (MIX) profiles. The strategy targets a constitutive region present...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
329079a0-3cc6-55d5-9052-f646031418b2
DOI
10.1101/2025.08.22.671732
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Tracking the Spread of a Naturally Occurring <i>Leishmania infantum</i> Mutant: A qPCR-Based Investigation in Strains and Clinical SamplesDOI 10.1101/2025.08.22.671732
Gene deletion as a possible strategy adopted by New World <i>Leishmania infantum</i> to maximize geographic dispersionSemantic proximity
Multilocus microsatellite typing (MLMT) reveals high genetic diversity of <i>Leishmania infantum</i> strains causing tegumentary leishmaniasis in northern ItalySemantic proximity
Genomic and epidemiological evidence for the emergence of a putative <i>L. donovani/L. infantum</i> hybrid with unusual epidemiology in Northern ItalySemantic proximity
Occurrence of multiple genotype infection caused by Leishmania infantum in naturally infected dogs.Semantic proximity
Insights on genomic profiles of drug resistance and virulence in a cohort of <i>Leishmania infantum</i> isolates from the Mediterranean areaSemantic proximity
Identification of Leishmania infantum Epidemiology, Drug Resistance and Pathogenicity Biomarkers with Nanopore SequencingSemantic proximity
Leishmania infections: Molecular targets and diagnosis.Semantic proximity
Direct quantitative PCR detects genetic biomarkers of antileishmanial drug resistance in clinical samples from dogs with leishmaniosisSemantic proximity
Genomic Drug Resistance Biomarkers in Leishmania infantum: from Quantitative Real- Time PCR (qPCR) to digital PCR (dPCR)Semantic proximity
Direct quantitative PCR detects genetic biomarkers of antileishmanial drug resistance in clinical samples from dogs with leishmaniosisSemantic proximity
Dirofilaria immitis: Genotyping Randomly Selected European Clinical Samples and USA Laboratory Isolates with Molecular Markers Associated with Macrocyclic Lactone Susceptibility and ResistanceSemantic proximity
Multilocus microsatellite typing (MLMT) reveals host-related population structure in Leishmania infantum from northeastern Italy.Semantic proximity
Select a neighboring publication to make it the new centre.