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Antimalarial resistance risk in Mozambique detected by a novel quadruplex droplet digital PCR assay

21 May 2024

Abstract excerpt

ABSTRACT While the Plasmodium falciparum malaria parasite continues to cause severe disease globally, Mozambique is disproportionally represented in malaria case totals. Acquisition of copy number variations (CNVs) in the parasite genome contributes to antimalarial drug resistance through overexpression of drug targets. Of interest, piperaquine resistance is associated with plasmepsin 2 and 3 CNVs ( pfpmp2 and...

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PMID: 38771031
DOI: 10.1128/aac.00346-24

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