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Measurement of gene amplifications related to drug resistance in Plasmodium falciparum using droplet digital PCR

27 Feb 2021

Abstract excerpt

BACKGROUND: Copy number variations (CNVs) of the Plasmodium falciparum multidrug resistance 1 (pfmdr1), P. falciparum plasmepsin2 (pfplasmepsin2) and P. falciparum GTP cyclohydrolase 1 (pfgch1) genes are associated with anti-malarial drug resistance in P. falciparum malaria. Droplet digital PCR (ddPCR) assays have been developed for accurate assessment of CNVs in several human genes. The aim of the present study...

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PMID: 33639924
DOI: 10.1186/s12936-021-03659-5

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