Article
A novel ENU-mutation in ankyrin-1 disrupts malaria parasite maturation in red blood cells of mice.
PloS one - 1 Jan 2012
Greth Andreas, Lampkin Shelley, Mayura-Guru Preethi, Rodda Fleur, Drysdale Karen, Roberts-Thomson Meredith, McMorran Brendan J, Foote Simon J, Burgio Gaétan
Abstract excerpt
The blood stage of the plasmodium parasite life cycle is responsible for the clinical symptoms of malaria. Epidemiological studies have identified coincidental malarial endemicity and multiple red blood cell (RBC) disorders. Many RBC disorders result from mutations in genes encoding cytoskeletal...
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