Towards genome-wide experimental genetics in the<i>in vivo</i>malaria model parasite<i>Plasmodium berghei</i>

Abstract excerpt

Plasmodium berghei was identified as a parasite of thicket rats (Grammomys dolichurus) and Anopheles dureni mosquitoes in African highland forests. Successful adaptation to a range of rodent and mosquito species established P. berghei as a malaria model parasite. The introduction of stable transfection technology, permitted classical reverse genetics strategies and thus systematic functional profiling of the gene...