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Genetic evidence for efficacy of targeting IL-2, IL-6, and TYK2 signaling in prevention of type 1 diabetes: A Mendelian randomization study

2023-12-17

Abstract excerpt

<h4>Background</h4> Type 1 diabetes is an autoimmune disease, which leads to insulin dependence. We investigated genetic evidence to support the repurposing of seven drugs, already licensed or in clinical phases of development, for prevention of type 1 diabetes. <h4>Methods</h4> We obtained genome-wide association study (GWAS) summary statistics for the risk of type 1 diabetes, whole-blood gene expression, and ser...

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Literature Corpus work
913112f3-8436-5284-aa4c-e0439e6ed14d
DOI
10.1101/2023.12.15.23300016
Open publication

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Genetic evidence for efficacy of targeting IL-2, IL-6, and TYK2 signaling in prevention of type 1 diabetes: A Mendelian randomization studyDOI 10.1101/2023.12.15.23300016
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